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Generally it’s quite simple to show the difference between 2D and 3D β€œspace”: Elements have dimensions as well! The problem is with names. Plate elements
Threedimensional (3D) culture models have the potential to bridge the gap between 2D in vitro models and in vivo models. The present review aims to describe the main 3D culture models currently available for studying cancer development and drug screening in oncology, and to discuss their added value and specific limitations. Usingexisting research, this paper aims to provide an overview of 2D and 3D in-vitro cardiac models and how they are produced, and discuss the advantages and limitations to each. 3. Methods. A review of the international published literature was completed in March 2022 of studies on 2D and 3D in-vitro cardiac models. Comparingbetween the 2D and 3D models, it would be more economical to run a 2D cell culture study than a 3D because less cells and time are required for these assays. It is also important to monitor and control reproducibility and quality control within the screening and a simpler 2D model would allow for this while keeping cost lower. However in recent years, 3D cell culture techniques have caused quite a stir in the scientific community. In contrast to 2D cell culture, cells in 3D cell culture can interact with their surroundings in all three dimensions. In 3D culture, cells often grow to form spheroids - cells that arrange themselves during proliferation into sphere-like jYtOWTt. 249 38 412 152 240 71 324 376 420

2d model vs 3d model